![parkinson disease free clinical trials las vegas nv parkinson disease free clinical trials las vegas nv](https://content.iospress.com/media/jpd/2020/10-3/jpd-10-3-jpd202128/jpd-10-jpd202128-g006.jpg)
One important study in southern California that sought to empower individuals with uncontrolled hypertension and diabetes by using digital pills to track adherence, wearable sensors, and a mobile application enrolled 109 participants, of whom 46% were Hispanic, 57% had an income of less than USD 20,000, and 52% had a high school education or less. The “digital divide”, the differential access to the internet and related technologies based on economic, geographic, and social factors, is an enormous barrier to the use of digital sensors and telehealth generally. Importantly, many – if not most – of the studies did not report on the demographic characteristics of the study participants and the impact upon underserved populations. Reflecting on the growth and maturation of studies of digital biomarkers, three of the eight studies had more than 100 participants, and one had nearly 1,000 participants. The eight studies predominantly focused on individuals with a particular disease, but the list of diseases examined (dementia, Parkinson disease, Huntington disease, acute pain, hypertension, diabetes, essential tremor, and chronic obstructive pulmonary disease ) is diverse and long. * Citation status based on a Google Scholar search performed on March 17, 2018. Note that some studies may be double counted, e.g., a study may have carried out activities both inside and outside the United States. Ten characteristics of the top eight publications. The top eight papers evaluated 1,290 individuals with digital pills, smartwatches, wearable devices, and electronic inhalers in disease states ranging from dementia to diabetes and from Parkinson disease to pain. Here, we present all of the nominated papers and profile the eight that received the most votes. The editorial board then selected up to ten papers to be recognized among 28 nominations. Nominations were solicited from the editorial board of Digital Biomarkers and supplemented by papers the editorial team identified from Web of Science, Google Scholar, and PubMed. Eligible papers reported on original research that evaluated a digital sensor (e.g., smartphone, wearable sensor, implantable device) in humans and was published in a peer-reviewed journal in 2017. To highlight some of the most promising work in the field, we have compiled a list of the top digital biomarkers papers from the past year. The use and evaluation of digital biomarkers, objective and quantifiable measures of biology, and health collected through digital devices is growing rapidly.